NAPLEX · One full practice exam

NAPLEX Practice Exam 5

100 case-based questions. Take it timed, score it by area, learn from every option.

Adetayo “Tayo” Ogunsanya, PharmD — licensed clinical pharmacist with more than ten years in managed care and clinical review. Questions are written from FDA labeling and current guidelines, with the source listed for every one. Not affiliated with or endorsed by NABP.

  • 100 questions, mostly short patient cases, with five options (A to E) on every item
  • Weighted to the NABP NAPLEX content outline (40% patient assessment and treatment planning, 25% foundational knowledge, 25% medication use process, 5% professional practice, 5% management), with every question tagged to its area
  • Calculation items included, from IV dilution and reconstitution to creatinine clearance and weight-based dosing
  • An explanation for every option, so you learn why the wrong answers fail, not just which letter is right
  • A 98-page PDF with an answer sheet and an area score sheet. The answer key and explanations are at the back, so nothing is revealed while you take the exam

Digital download · Immediate access · 30-day money-back guarantee

Cover of NAPLEX Practice Exam 5, 100 questions

Three questions from the exam

These are three of the 100, with every option explained, so you can judge the style before you buy.

Sample question 12

A 3-year-old with tympanostomy tubes has acute otitis media with otorrhea and is prescribed ciprofloxacin 0.3%/dexamethasone 0.1% otic suspension. Which counseling for the parent is consistent with the FDA label?

  • A. Keep the bottle refrigerated, shake, give 4 drops cold twice daily for 7 days to reduce swelling, then pump the tragus 5 times
  • B. Warm the bottle in your hand 1 to 2 minutes, shake, give 4 drops twice daily for 7 days, and save leftover drops for next time
  • C. Warm the bottle in your hand 1 to 2 minutes, shake, give 4 drops twice daily for 7 days, and use them in the eyes if they redden
  • D. Warm the bottle in your hand 1 to 2 minutes, do not shake, give 2 drops four times daily for 10 days, then pump the tragus 5 times
  • E. Warm the bottle in your hand 1 to 2 minutes, shake, give 4 drops twice daily for 7 days, then pump the tragus 5 times
Show the answer and explanations

Answer: E.

  • A. Incorrect. The label says to warm the suspension in the hand to avoid dizziness, which may result from instilling a cold suspension; it is stored at 20 to 25 C.
  • B. Incorrect. The label says to discard the unused portion after therapy is completed.
  • C. Incorrect. The label states the suspension is for otic use (ears) only, and not for ophthalmic use, or for injection.
  • D. Incorrect. The label says to shake well immediately before use and gives 4 drops twice daily for 7 days.
  • E. Correct. For AOMT the label directs 4 drops into the affected ear twice daily for 7 days, warming the bottle in the hand for 1 to 2 minutes to avoid dizziness from a cold suspension, shaking well immediately before use, lying with the affected ear up, pumping the tragus 5 times, and keeping the position for 60 seconds.

Sample question 33

A 27-year-old woman at 14 weeks of gestation has vulvar itching and a thick, curdy discharge; a KOH wet mount shows budding yeast, and she is diagnosed with uncomplicated vulvovaginal candidiasis. She asks for the single-dose oral fluconazole her sister used. According to the CDC STI Treatment Guidelines, 2021, which treatment is most appropriate?

  • A. Fluconazole 150 mg by mouth as a single dose, taken today
  • B. Fluconazole 150 mg by mouth, then a second dose 72 hours later
  • C. Miconazole 2% cream 5 g intravaginally daily for 7 days
  • D. Miconazole 1,200 mg vaginal suppository, one suppository for 1 day
  • E. Boric acid 600 mg in a gelatin capsule vaginally daily for 3 weeks
Show the answer and explanations

Answer: C.

  • A. Incorrect. The guidelines state a single 150-mg dose of fluconazole might be associated with spontaneous abortion and congenital anomalies and should not be used in pregnancy.
  • B. Incorrect. Two sequential 150-mg fluconazole doses, the second 72 hours after the first, is one guideline option for severe VVC, but the guidelines state that only topical azoles applied for 7 days are recommended in pregnancy and that oral fluconazole should not be used.
  • C. Correct. The guidelines state only topical azole therapies, applied for 7 days, are recommended for pregnant women; miconazole 2% cream 5 g intravaginally daily for 7 days is a listed topical azole regimen.
  • D. Incorrect. Although topical, this is a 1-day regimen; the guidelines recommend topical azoles applied for 7 days during pregnancy.
  • E. Incorrect. Boric acid 600 mg in a gelatin capsule vaginally once daily for 3 weeks is the guideline option if non-albicans VVC recurs, not treatment of uncomplicated VVC in pregnancy.

Sample question 80

A father picks up Baqsimi (glucagon) 3 mg nasal powder, a two-pack, for his 15-year-old son with type 1 diabetes. He plans to keep one device in the boy's backpack and asks how to store it and get it ready. Which counseling is consistent with the FDA label?

  • A. Keep each device in its shrink-wrapped tube at up to 86 F (30 C); do not test it
  • B. Take the device out of its tube and keep it loose in the backpack so it can be used faster
  • C. Push the plunger once at home to confirm the device works, then return it to the tube
  • D. Have the person inhale deeply through the nose during the dose so the powder is absorbed
  • E. If there is no response in 15 minutes, give the powder left in the same device as a second dose
Show the answer and explanations

Answer: A.

  • A. Correct. The label says to store at temperatures up to 86 F (30 C) in the shrink-wrapped tube, keep it in the tube until ready to use, and not push the plunger or test the device before administration.
  • B. Incorrect. The label says to keep Baqsimi in the shrink-wrapped tube until ready to use; if the tube has been opened, the device may have been exposed to moisture and may not work as expected.
  • C. Incorrect. The label instructs patients and caregivers not to push the plunger or test the device before administration; each device contains one dose.
  • D. Incorrect. The label states the dose does not need to be inhaled.
  • E. Incorrect. Each device contains one dose and cannot be reused; if there is no response after 15 minutes, an additional dose from a new device may be given while waiting for emergency help.

Built to the NABP blueprint

The NABP NAPLEX Content Outline (effective 1 May 2025) weights the exam across five areas. This practice exam follows the same weights, so your score by area shows where you stand against how the real exam is distributed. It is shorter than the real exam and is not adaptive. Check the current NABP candidate bulletin for anything administrative, because NABP can change it.

25%Foundational Knowledge
25%Medication Use Process
40%Person-Centered Assessment and Treatment Planning
5%Professional Practice
5%Pharmacy Management and Leadership

Is this for you?

Yes, if…

You are preparing for the NAPLEX and want a realistic, case-based check of where you stand by content area, with explanations that teach the reasoning.

No, if…

You are looking for released or recalled NABP questions. These questions are written for this exam, modeled on the NAPLEX style and blueprint. They are not NABP items. If you are preparing for the MPJE instead, see the UMPJE practice exam.

Questions before you buy

What if it isn't right for me?

Email support@doctayo.com within 30 days and you get your money back in full. See the refund policy.

What format is it?

A 98-page PDF, delivered by email immediately after purchase. Your copy carries your email address and order number on each page, so please do not share it. There is no subscription and no expiry.

Are these real NAPLEX questions?

No. Every question was written for this exam from the cited sources. They follow the NAPLEX style (a short case, five options, one best answer) and the NABP content weighting, but they are not released or recalled NABP items.

Does a good score mean I will pass?

No. NABP sets the real passing standard and this exam is shorter and not adaptive. Use your area scores to see where your preparation is thin.

How current is it?

Questions were written in November 2026 from FDA labeling and current guidelines. Sources were checked in November 2026, and each explanation lists its source basis and, where a source could be checked, a reference number. Drug information changes, so confirm anything you rely on in practice at the source. If you find an error, email support@doctayo.com.

See where you stand.

100 questions · every option explained · scored by NABP area

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NAPLEX Practice Exam 5 · $50

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